The Medical Letter TML n. 8/2016
Nr. 08 del 15/04/2016
TML n. 8/2016 – UNA NUOVA ASSOCIAZIONE DI QUATTRO FARMACI PER L’HIV
La US Food and Drug Administration (FDA) ha approvato Genvoya (Gilead Sciences negli USA; farmaco approvato in Europa, ma non disponibile in commercio in Italia), un’associazione precostituita che comprende l’inibitore dell’attività di strand transfer dell’integrasi (INSTI) elvitegravir, il potenziatore farmacocinetico cobicistat e gli inibitori nucleosidici/nucleotidici della trascrittasi inversa (NRTI) emtricitabina e tenofovir alafenamide, per il trattamento dell’infezione da HIV-1 nei pazienti di età pari o superiore ai 12 anni. Si tratta della prima approvazione per il tenofovir alafenamide (TAF), un profarmaco del tenofovir. Nel 2012 era stato approvato Stribild (Gilead Sciences), un’associazione precostituita di elvitegravir, cobicistat, emtricitabina e tenofovir disoproxil fumarato (TDF) (1).
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