The Medical Letter TML n. 18/2016
Nr. 18 del 15/09/2016
TML n. 18/2016 – IN BREVE: Uridina triacetato per il sovradosaggio di fluorouracile
La US Food and Drug Administration (FDA) ha approvato l’analogo della pirimidina uridina triacetato (Vistogard-Wellstat Therapeutics) per il trattamento di emergenza del sovradosaggio di fluorouracile (5-FU) o capecitabina (Xeloda-Roche; disponibile anche come medicinale equivalente) o di una tossicità grave che si verifica entro le 96 ore successive alla somministrazione di uno di questi farmaci. Il fluorouracile è un antimetabolita citotossico utilizzato per trattare il cancro al seno, il cancro colorettale e altre forme di cancro; la capecitabina è un profarmaco orale del fluorouracile.
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