The Medical Letter TML n. 7/2015
Nr. 07 del 01/04/2015
TML n. 7/2015 – BUNAVAIL: UNA FORMULAZIONE ALTERNATIVA DI BUPRENORFINA/NALOXONE PER TRATTARE LA DIPENDENZA DA OPPIOIDI
La US Food and Drug Administration (FDA) ha approvato una nuova associazione in forma di pellicola buccale contenente l’agonista parziale degli oppioidi buprenorfina e l’antagonista degli oppioidi naloxone (Bunavail-BioDelivery Sciences in USA; non disponibile in commercio in Italia) e destinata alla terapia di mantenimento della dipendenza da oppioidi. La medesima associazione è disponibile in Italia in forma di compresse sublinguali (Suboxone-RB Pharmaceuticals). Secondo la casa farmaceutica produttrice di Bunavail, la nuova formulazione sarebbe superiore a quella sublinguale, in virtù della comodità della somministrazione buccale e del migliore assorbimento ematico, tale da consentire l’impiego di dosaggi più contenuti.
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