The Medical Letter TML n. 10/2015
Nr. 10 del 15/05/2015
TML n. 10/2015 – INIBITORI DEL VEGF PER L’AMD E L’EDEMA MACULARE DIABETICO
Il fattore di crescita dell’endotelio vascolare (VEGF) è un importante mediatore della neurovascolarizzazione nella forma essudativa della degenerazione maculare legata all’età (AMD) e nell’edema maculare diabetico. Induce l’angiogenesi e aumenta la permeabilità e l’infiammazione vascolare. Gli inibitori del VEGF riducono le perdite dai vasi sanguigni, prevengono la proliferazione di nuovi vasi anomali, diminuiscono il gonfiore della retina e migliorano l’acuità visiva nei pazienti con AMD neovascolare (essudativa) ed edema maculare diabetico (1, 2). Questi farmaci vengono somministrati periodicamente sotto forma di iniezioni intravitreali in anestesia locale.
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