The Medical Letter TML n. 13/2015
Nr. 13 del 01/07/2015
TML n. 13/2015 – NETUPITANT/PALONOSETRON (AKYNZEO) PER LA NAUSEA E IL VOMITO INDOTTI DA CHEMIOTERAPIA
La US Food and Drug Administration (FDA) ha approvato Akynzeo (Helsinn/Eisai; il farmaco ha ricevuto il parere positivo del CHMP il 26/03/2015; non disponibile in commercio in Italia), un’associazione orale precostituita di netupitant, un antagonista della sostanza P del recettore della neurochinina 1 (NK1), e palonosetron, un antagonista del recettore della serotonina 3 (5-HT3), per la prevenzione della nausea e del vomito acuti e tardivi associati alla chemioterapia antineoplastica negli adulti. Akynzeo è il primo prodotto ad associare farmaci appartenenti a queste due classi. Il palonosetron (Aloxi-Italfarmaco) è disponibile anche come agente singolo per la prevenzione della nausea e del vomito postoperatori e indotti da chemioterapia (1). Il netupitant è il secondo antagonista dei recettori NK1/P a essere approvato negli Stati Uniti; l’aprepitant (Emend-MSD Italia) è stato il primo (2).
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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