The Medical Letter TML n. 23/2014
Nr. 23 del 01/12/2014
TML n. 23/2014 – VORAPAXAR PER LA PREVENZIONE DEGLI EVENTI TROMBOTICI CARDIOVASCOLARI
La US Food and Drug Administration (FDA) ha approvato il vorapaxar (Zontivity-Merck, negli USA; in corso di valutazione da parte delle autorità regolatorie europee), un antagonista orale del recettore-1 attivato dalle proteasi (PAR-1, protease-activated receptor-1), per l’impiego in associazione ad acido acetilsalicilico (ASA) e/o a clopidogrel per la riduzione del rischio di eventi trombotici cardiovascolari in pazienti con arteriopatia periferica o con una storia di infarto miocardico (IM). Il vorapaxar è il primo antagonista del recettore PAR-1 approvato dalla FDA.
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