The Medical Letter TML n. 19/2014
Nr. 19 del 01/10/2014
TML n. 19/2014 – CERITINIB PER IL CARCINOMA POLMONARE NON A PICCOLE CELLULE
Il ceritinib (Zykadia-Novartis, negli USA; in corso di valutazione da parte delle autorità regolatorie europee), un inibitore delle tirosin-chinasi per via orale, ha ricevuto l’approvazione accelerata della US Food and Drug Administration (FDA) per il trattamento del carcinoma polmonare non a piccole cellule metastatico (NSCLC, non-small cell lung cancer) positivo per la chinasi del linfoma anaplastico (ALK, anaplastic lymphoma kinase) in pazienti con progressione di malattia o intolleranti al crizotinib (Xalkori-Pfizer Italia). È il secondo inibitore delle tirosin-chinasi approvato per il NSCLC metastatico ALK-positivo, dopo il crizotinib (1). Le traslocazioni del gene ALK sono presenti in circa il 5% dei tumori polmonari (2) e si verificano principalmente in soggetti non fumatori affetti da adenocarcinoma polmonare.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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