The Medical Letter TML n. 13/2014
Nr. 13 del 01/07/2014
TML n. 13/2014 – ESTROGENI CONIUGATI/BAZEDOXIFENE PER I SINTOMI MENOPAUSALI E LA PREVENZIONE DELL’OSTEOPOROSI
La US Food and Drug Administration (FDA) ha approvato Duavee (Pfizer; negli USA), un’associazione precostituita contenente estrogeni coniugati e bazedoxifene, un nuovo modulatore selettivo dei recettori per gli estrogeni (SERM, selective estrogen receptor modulator), per il trattamento dei sintomi vasomotori di grado moderato-grave e per la prevenzione dell’osteoporosi in donne in postmenopausa con utero integro. Il prodotto è in attesa dell’approvazione delle autorità regolatorie in Europa, dove è attualmente in commercio il bazedoxifene come farmaco singolo (Conbriza-Pfizer Italia). Il bazedoxifene è un agonista/antagonista degli estrogeni dotato di effetti estrogeno-simili sull’osso e di effetti antiestrogenici sull’utero. È il secondo SERM approvato per la prevenzione dell’osteoporosi; il raloxifene (Evista-Daiichi Sankyo, e altri) è disponibile come farmaco singolo approvato per la stessa indicazione.
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