The Medical Letter TML n. 5/2014
Nr. 05 del 01/03/2014
TML n. 5/2014 – SIMEPREVIR PER L’EPATITE C CRONICA
La Us Food and Drug Administration (FDA) ha approvato due nuovi farmaci per il trattamento dell’infezione cronica da virus dell’epatite C (HCV, hepatitis C virus). Il simeprevir (Olysio-Janssen, negli USA; in attesa di approvazione europea) è il terzo inibitore delle proteasi per via orale approvato per l’impiego in associazione a interferone pegilato (peginterferone) e ribavirina per il trattamento dell’infezione cronica da HCV di genotipo 1 in soggetti adulti con malattia epatica compensata. Il telaprevir (Incivo-Janssen-Cilag) e il boceprevir (Victrelis-MSD Italia) sono stati approvati dalla FDA nel 2011 per la stessa indicazione. Il sofosbuvir (Sovaldi-Gilead, negli USA; non disponibile in commercio in Italia), un analogo nucleotidico inibitore delle polimerasi approvato per l’impiego con o senza interferone per il trattamento dell’infezione causata da diversi genotipi di HCV, sarà trattato nel prossimo numero di The Medical Letter.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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