The Medical Letter TML n. 20/2013
Nr. 20 del 15/10/2013
TML n. 20/2013 – TRASTUZUMAB EMTANSINE PER IL CARCINOMA MAMMARIO METASTATICO HER-2 POSITIVO
Il trastuzumab emtansine (negli USA: ado-trastuzumab emtansine, Kadcyla-Genentech), un anticorpo diretto contro HER-2 (human epidermal growth factor receptor 2) coniugato con un farmaco inibitore dei microtubuli, è stato approvato dalla US Food and Drug Administration (FDA) per il trattamento per via endovenosa (EV) del carcinoma mammario metastatico HER-2 positivo in pazienti trattate in precedenza con trastuzumab (Herceptin-Roche) e un taxano. Su richiesta della FDA è stato aggiunto al nome della molecola il prefisso “ado”, per distinguerla dal trastuzumab. In Europa, il trastuzumab emtansine (Kadcyla-Roche) ha ricevuto il parere positivo del CHMP il 20 settembre 2013 ed è in attesa di approvazione definitiva dell’EMA, prevista per fine anno (1).
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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