The Medical Letter TML n. 21/2012
Nr. 21 del 01/11/2012
TML n. 21/2012 – IN BREVE: Rotigotina transdermica
Una formulazione in cerotto di rotigotina (Neupro-UCB Pharma), un agonista della dopamina non ergolinico, è stata reintrodotta in commercio negli Stati Uniti dopo quattro anni di assenza. Originariamente approvato dalla FDA nel 2007 per il trattamento del morbo di Parkinson (PD) in fase precoce (1), il prodotto era stato ritirato dal commercio nel 2008 a causa di una cristallizzazione del farmaco nel cerotto, che avrebbe potuto causare problemi di sottodosaggio. Il nuovo cerotto ha indicazioni un po’ più ampie rispetto al precedente; è approvato per l’impiego in pazienti con morbo di Parkinson in qualsiasi stadio e per la sindrome delle gambe senza riposo (RLS) di grado moderato-grave.
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