The Medical Letter TML n. 21/2011
Nr. 21 del 01/11/2011
TML n. 21/2011 – GABAPENTIN ENACARBIL PER LA SINDROME DELLE GAMBE SENZA RIPOSO
Il gabapentin enacarbil (Horizant-GlaxoSmithKline, negli USA; non disponibile in commercio in Italia), una nuova formulazione di gabapentin in compresse a rilascio prolungato (ER, extended-release), è stato approvato dalla US Food and Drug Administration (FDA) per il trattamento della sindrome delle gambe senza riposo (RLS, restless legs syndrome) di grado moderato-grave. La formulazione a rilascio immediato (IR, immediate release) di gabapentin (Neurontin-Pfizer Italia, e altri; disponibile anche come medicinale equivalente), approvata per il trattamento dell’epilessia e del dolore neuropatico periferico, viene utilizzata da molti anni per il trattamento della RLS (1). Un’altra formulazione di gabapentin in compresse ER (Gralise, negli USA; non disponibile in commercio in Italia) è stata approvata dalla FDA per il trattamento della nevralgia posterpetica.
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