The Medical Letter TML n. 6/2011
Nr. 06 del 15/03/2011
TML n. 6/2011 – PEGLOTICASE PER IL TRATTAMENTO DELLA GOTTA REFRATTARIA
Il pegloticase (Krystexxa-Savient, in USA), una formulazione pegilata dell’urato ossidasi, è stato approvato dalla US Food and Drug Administration (FDA) per il trattamento endovenoso (EV) della gotta sintomatica cronica in soggetti adulti che non hanno risposto alla terapia con dosi massime di un inibitore della xantina ossidasi, quale l’allopurinolo (Zyloric e Allurit-Teofarma; disponibile anche come medicinale equivalente). A breve è prevista la presentazione della domanda di autorizzazione al commercio del pegloticase anche presso le autorità regolatorie europee. Il pegloticase è il secondo nuovo farmaco approvato per la gotta dopo più di 40 anni; nel 2009 è stato approvato il febuxostat (Uloric-Takeda, in USA; in Italia Adenuric-Menarini), un nuovo inibitore della xantina ossidasi (1).
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