The Medical Letter TML n. 1/2015
Nr. 01 del 01/01/2015
TML n. 1/2015 – UN’ASSOCIAZIONE DI LEDIPASVIR E SOFOSBUVIR PER L’EPATITE C
La FDA ha approvato un’associazione precostituita di sofosbuvir e ledipasvir (Harvoni-Gilead, negli USA; approvato in Europa il 17 novembre 2014 e non attualmente disponibile in commercio in Italia), due agenti antivirali ad azione diretta per uso orale, per il trattamento dell’infezione cronica da virus dell’epatite C (HCV, hepatitis C virus) di genotipo 1. Il genotipo 1 è responsabile del 70-80% delle infezioni da HCV negli Stati Uniti. Il sofosbuvir (Sovaldi-Gilead Sciences) è stato approvato in precedenza per l’impiego in associazione ad altri farmaci antivirali per il trattamento dell’infezione da HCV. Il ledipasvir è un nuovo farmaco.
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