The Medical Letter TML n. 11/2013
Nr. 11 del 01/06/2013
TML n. 11/2013 – IN BREVE: Rischio di tumori con calcitonina di salmone
Due comitati consultivi della FDA hanno recentemente concluso che l’impiego di una formulazione in spray nasale dell’ormone peptidico calcitonina di salmone per il trattamento dell’osteoporosi postmenopausale è associato a un aumento del rischio di tumori. La calcitonina di salmone è disponibile negli Stati Uniti sotto forma di spray nasale (Miacalcin, Fortical) e in formulazione iniettabile (Miacalcin injection) per l’impiego nell’osteoporosi (1).
Le preoccupazioni circa il rischio di tumori derivano dai risultati di una metanalisi non pubblicata di 18 studi che hanno valutato lo spray nasale Miacalcin, nella quale è emerso che il rischio di qualsiasi tumore era 1,54 volte più alto (IC al 95%: 1,06-2,23) nelle pazienti trattate con il farmaco rispetto ai controlli (2).
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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