The Medical Letter TML n. 1/2015
Nr. 01 del 01/01/2015
TML n. 1/2015 – PEMBROLIZUMAB PER IL MELANOMA METASTATICO
La FDA ha approvato il pembrolizumab (Keytruda-Merck, negli USA; in attesa di approvazione da parte della Commissione Europea), un anticorpo che blocca il recettore PD-1 umano (programmed death receptor-1) per il trattamento del melanoma inoperabile o metastatico che ha progredito dopo trattamento con ipilimumab (Yervoy-Bristol-Myers Squibb) e con un inibitore BRAF, nei pazienti positivi alla mutazione BRAF V600. È il primo inibitore PD-1 immesso in commercio negli Stati Uniti. Il nivolumab, un altro inibitore PD-1, è disponibile in Giappone. Il pembrolizumab era noto in passato come lambrolizumab.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
Se sei già abbonato accedi.
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