The Medical Letter TML n. 12/2012
Nr. 12 del 15/06/2012
TML n. 12/2012 – IN BREVE: Asparaginasi da Erwinia chrysanthemi per la leucemia linfoblastica acuta
La FDA ha approvato l’asparaginasi prodotta da Erwinia chrysanthemi (Erwinaze-EUSA; crisantaspase, in Europa Erwinase), un enzima asparagina-specifico derivato dal bacillo gram-negativo Erwinia chrysanthemi, per l’impiego in associazione ad altri farmaci chemioterapici per il trattamento della leucemia linfoblastica acuta (LLA) in pazienti che hanno sviluppato reazioni allergiche all’asparaginasi derivata da Escherichia coli (Elspar; e pegaspargase [Oncaspar-Enzon Pharm.]).
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