The Medical Letter TML n. 18/2011
Nr. 18 del 15/09/2011
TML n. 18/2011 – TELAPREVIR E BOCEPREVIR PER L’EPATITE C CRONICA
Il telaprevir (Incivek-Vertex, in USA) e il boceprevir (Victrelis-Merck, in USA) sono stati approvati dalla US Food and Drug Administration (FDA) per uso orale in associazione a interferone pegilato e ribavirina per il trattamento dell’infezione cronica da virus dell’epatite C (HCV) di genotipo 1 in soggetti adulti con malattia epatica compensata. Sia il telaprevir sia il boceprevir sono stati sviluppati specificamente per inibire le proteasi NS3/4A responsabili del clivaggio delle poliproteine codificate dal virus HCV di genotipo 1. In Europa il telaprevir è in attesa di approvazione definitiva dopo il parere positivo del Comitato per i Prodotti Medicinali per uso umano (CHMP) dell’EMA del 21 luglio 2011, e sarà commercializzato da Janssen con il nome commerciale Incivo. Il boceprevir (Victrelis) ha ricevuto l’approvazione dell’EMA il 18 luglio 2011 e la sua immissione in commercio in Italia è prevista per il prossimo anno.
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