The Medical Letter TML n. 19/2013
Nr. 19 del 01/10/2013
TML n. 19/2013 – DABRAFENIB E TRAMETINIB PER IL TRATTAMENTO DEL MELANOMA METASTATICO
La US Food and Drug Administration (FDA) ha approvato due nuovi inibitori delle tirosin-chinasi, somministrabili per via orale, per il trattamento del melanoma non operabile o metastatico: il dabrafenib (Tafinlar-GlaxoSmithKline; approvato in Europa e non ancora disponibile in commercio in Italia) per i melanomi positivi per la mutazione V600E del gene BRAF e il trametinib (Mekinist-GlaxoSmithKline; in attesa di approvazione in Europa) per i melanomi che presentano una mutazione BRAF V600E o V600K. Il dabrafenib non è raccomandato nei pazienti affetti da melanoma senza mutazione di BRAF (wild-type), mentre il trametinib non è raccomandato in quelli trattati in precedenza con un inibitore di BRAF.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
Se sei già abbonato accedi.
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