The Medical Letter TML n. 19/2018
Nr. 19 del 01/10/2018
TML n. 19/2018 UN NUOVO ANTAGONISTA ORALE DEL GNRH PER IL DOLORE DA ENDOMETRIOSI
La US Food and Drug Administration (FDA) ha approvato l’elagolix (Orilissa-AbbVie negli USA; non disponibile in commercio in Italia), un antagonista orale dell’ormone di rilascio delle gonadotropine (GnRH), per la gestione del dolore da moderato a intenso associato a endometriosi.
MECCANISMO D’AZIONE – L’elagolix si lega in maniera competitiva ai recettori ipofisari del GnRH, inibendo la segnalazione del GnRH, riducendo la secrezione dell’ormone follicolo-stimolante (FSH) e dell’ormone luteinizzante (LH) da parte dell’ipofisi e riducendo la produzione ovarica di estradiolo e progesterone.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
Se sei già abbonato accedi.
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