The Medical Letter TML n. 20 / 2020
Nr. 20 del 15/10/2020
TML n. 20/2020 CENOBAMATO PER LE CRISI EPILETTICHE FOCALI
La US Food and Drug Administration (FDA) ha approvato il cenobamato (Xcopri-SK Life Science negli USA; non disponibile in commercio in Italia) per il trattamento orale delle crisi epilettiche a esordio parziale (focali) negli adulti.
TRATTAMENTO STANDARD – Il trattamento delle crisi focali dovrebbe iniziare con un solo farmaco antiepilettico (AED), come il levetiracetam, la lamotrigina o la carbamazepina; il dosaggio dovrebbe essere gradualmente aumentato finché le crisi epilettiche non risultino sotto controllo o gli effetti avversi non diventino intollerabili. Se le crisi convulsive persistono, si dovrebbe tentare almeno un farmaco alternativo (talvolta anche due) come monoterapia, prima di prendere in considerazione l’uso concomitante di due farmaci. (1) Sebbene esistano diversi AED per il trattamento delle crisi focali, molti pazienti rimangono refrattari al trattamento.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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