The Medical Letter TML n. 21 / 2024
Nr. 21 del 14/10/2024
TML n. 21 / 2024 Un vaccino pneumococcico coniugato a 21 virus
La US Food and Drug Administration (FDA) ha autorizzato Capvaxive (PCV21; Merck, in USA; non disponibile in commercio in Italia), un vaccino pneumococcico coniugato 21-valente, per la prevenzione della malattia pneumococcica invasiva (IPD) e della polmonite pneumococcica negli adulti. Negli Stati Uniti e in Italia sono attualmente disponibili altri quattro vaccini contro lo pneumococco: tre [Prevenar 20 (PCV20), Vaxneuvance (PCV15) e Prevenar 13 (PCV13)] sono vaccini coniugati autorizzati per l'uso in persone di età ≥6 settimane e Pneumovax 23 (PPSV23) è un vaccino polisaccaridico pneumococcico autorizzato per l'uso in persone di età ≥2 anni (tabella 1). (1)
MALATTIA PNEUMOCOCCICA – Lo Streptococcus pneumoniae è una causa comune di polmonite batterica. Gli adulti di età ≥65 anni e le persone con determinate condizioni cliniche e di immunocompromissione (figura 1 online) sono a maggior rischio di sviluppare l'IPD. Negli Stati Uniti, la vaccinazione contro lo S. pneumoniae ha ridotto sostanzialmente l'incidenza della malattia pneumococcica nei bambini e negli adulti.
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