The Medical Letter TML n. 2/2014
Nr. 02 del 15/01/2014
TML n. 2/2014 – Addendum: Ospemifene per la dispareunia (Medical Letter 2013; 42:69)
Alcuni lettori negli Stati Uniti sono in disaccordo con le nostre raccomandazioni sul fatto che le donne in postmenopausa con utero intatto, trattate con l’agonista/antagonista orale degli estrogeni ospemifene (Osphena, negli USA) per la dispareunia, dovrebbero assumere anche un progestinico (1). L’ospemifene esercita degli effetti agonisti sull’endometrio e nel foglietto illustrativo di Osphena è scritto: “In generale, quando viene prescritto un prodotto con effetti agonisti estrogenici sull’endometrio a una donna in postmenopausa con utero intatto, dovrebbe essere presa in considerazione l’aggiunta di un progestinico per ridurre il rischio di carcinoma dell’endometrio”.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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