The Medical Letter TML n. 2/2014
Nr. 02 del 15/01/2014
TML n. 2/2014 – IDROCODONE/CLORFENAMINA
La US Food and Drug Administration (FDA) ha approvato una soluzione orale (Vituz-Hawthorne, negli USA; non disponibile in commercio in Italia) contenente due vecchi farmaci, l’oppioide ad azione centrale idrocodone bitartrato e l’antistaminico H1 di prima generazione clorfenamina maleato, per la riduzione della tosse e degli altri sintomi associati alle allergie delle vie respiratorie superiori o al raffreddore comune in pazienti adulti. Sono disponibili in commercio negli Stati Uniti diversi prodotti a rilascio prolungato contenenti idrocodone e clorfenamina nelle formulazioni in capsule e sospensione orale, utilizzati da anni per indicazioni simili. Vituz è stato classificato come sostanza controllata in tabella III, ma la FDA ha chiesto alla Drug Enforcement Agency (DEA) di riclassificare i prodotti a base di idrocodone in tabella II.
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