The Medical Letter TML n. 2/2017
Nr. 02 del 15/01/2017
TML n. 2/2017 – METFORMINA PER IL PREDIABETE
La biguanide orale metformina (Glucophage-Bruno Farmaceutici e altri) è in genere il farmaco di elezione per il trattamento iniziale del diabete di tipo 2. Viene anche utilizzata per prevenire, o perlomeno ritardare, la comparsa del diabete nei pazienti considerati ad alto rischio di sviluppare la malattia. Le linee guida recenti raccomandano di prendere in considerazione l’uso della metformina nei pazienti affetti da prediabete (glicemia plasmatica a digiuno 100-125 mg/dl, glicemia 2 ore post-carico 140-199 mg/dl o A1C 5,7-6,4%), specialmente nei soggetti di età inferiore ai 60 anni, in coloro che hanno un BMI > 35 kg/m2 o che presentano un’anamnesi di diabete gestazionale (1). La metformina non è stata approvata dalla US Food and Drug Administration (FDA) per questo utilizzo.
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