The Medical Letter TML n. 23 / 2024
Nr. 23 del 11/11/2024
TML n. 23 / 2024 Xanomelina/trospio per la schizofrenia
La US Food and Drug Administration (FDA) ha approvato Cobenfy (BMS; non disponibile in commercio in Italia), una combinazione orale a dose fissa dell'agonista muscarinico xanomelina e dell'antagonista muscarinico periferico trospio cloruro, per il trattamento della schizofrenia negli adulti. Si tratta del primo farmaco antipsicotico approvato negli Stati Uniti per il trattamento della schizofrenia che non blocca i recettori della dopamina. Si tratta della prima approvazione per la xanomelina; il trospio è disponibile da molti anni anche in Italia per il trattamento della vescica iperattiva.
TRATTAMENTO STANDARD – Lo standard di cura per il trattamento della schizofrenia è costituito dai farmaci che hanno come bersaglio i recettori della dopamina; in prima battuta vengono solitamente utilizzati gli antipsicotici di seconda generazione. Sono molto efficaci, ma possono causare aumento di peso, iperglicemia e sintomi motori extrapiramidali.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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