The Medical Letter n.23 / 2020
Nr. 23 del 01/12/2020
TML n. 23/2020 TEMPISTICHE DI SOMMINISTRAZIONE DEL REMDESIVIR NELLA COVID-19
Il remdesivir (Veklury-Gilead Sciences), un farmaco antivirale in fase sperimentale somministrato tramite infusione EV, è ora disponibile negli Stati Uniti grazie a un’autorizzazione all’uso in emergenza (EUA, Emergency Use Authorization) rilasciata dalla US Food and Drug Administration (FDA) per il trattamento della malattia da coronavirus 2019 (COVID-19) in tutti i pazienti ricoverati in ospedale. In Italia il farmaco è approvato per solo uso ospedaliero per il trattamento della COVID-19. Una precedente EUA ne limitava l’uso ai pazienti ricoverati in ospedale che presentavano malattia grave.
MECCANISMO D’AZIONE – Il remdesivir è un profarmaco analogo nucleotidico dell’adenosina che inibisce la replicazione virale legandosi alla RNA-polimerasi RNA-dipendente. Nei modelli in vitro e animali è attivo contro SARS CoV-2 e altri coronavirus.
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