The Medical Letter TML n. 24/2011
Nr. 24 del 15/12/2011
TML n. 24/2011 – QUETIAPINA E PROLUNGAMENTO DELL’INTERVALLO QT
La US Food and Drug Administration (FDA) ha chiesto al produttore dell’antipsicotico di seconda generazione quetiapina (Seroquel-AstraZeneca) di aggiungere un’avvertenza sulle etichette e nel foglietto illustrativo per informare che il farmaco non dovrebbe essere utilizzato in associazione ad altri farmaci che prolungano l’intervallo QTc all’elettrocardiogramma (vedi tabella sotto riportata). L’avvertenza si basa unicamente su segnalazioni postmarketing di prolungamento dell’intervallo QT in pazienti che avevano assunto dosi eccessive di farmaco, che erano affetti da malattie concomitanti o che erano in trattamento con altri farmaci che possono causare squilibri elettrolitici o prolungare l’intervallo QT. Il prolungamento dell’intervallo QT può causare torsione di punta (torsades de pointes, TdP), un’aritmia cardiaca potenzialmente fatale.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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