The Medical Letter TML n. 24/2017
Nr. 24 del 15/12/2017
TML n. 24/2017 – TISAGENLECLEUCEL PER LA LLA
La US Food and Drug Administration (FDA) ha approvato il tisagenlecleucel (Kymriah-Novartis negli Stati Uniti; farmaco non disponibile in commercio in Italia), un prodotto cellulare geneticamente modificato e personalizzato, per il trattamento della leucemia linfoblastica acuta (LLA) da precursori delle cellule B recidivante o refrattaria nei pazienti di età pari o inferiore ai 25 anni. Le cellule T del paziente vengono geneticamente modificate per esprimere i recettori chimerici per l’antigene (CAR) e poi reinfuse. Kymriah è la prima immunoterapia CAR-T a essere disponibile negli Stati Uniti. Si prevede entro breve l’approvazione di un prodotto CAR-T per il linfoma non Hodgkin a cellule B.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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