The Medical Letter n. 3 / 2021
Nr. 03 del 01/02/2021
TML n.3 / 2021 BALOXAVIR PER LA PROFILASSI POST-ESPOSIZIONE DELL’INFLUENZA
La FDA ha approvato l’inibitore orale dell’endonucleasi acida della polimerasi baloxavir marboxil (Xofluza-Genentech negli USA; non disponibile in commercio in Italia) per la profilassi post-esposizione dell’influenza in pazienti di età pari o superiore a 12 anni. Il baloxavir è stato approvato per il trattamento dell’influenza acuta non complicata in pazienti di età pari o superiore a 12 anni nel 2018. Due inibitori della neuraminidasi sono approvati dalla FDA per la profilassi dell’influenza: oseltamivir (Tamiflu-Roche; medicinali equivalenti per solo uso ospedaliero) in pazienti di età pari o superiore a 1 anno e zanamivir (Relenza-GSK) in pazienti di età pari o superiore a 5 anni. A differenza di oseltamivir e zanamivir, il baloxavir non è approvato dalla FDA per la profilassi pre-esposizione dell’influenza con focolai in corso.
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