The Medical Letter TML n. 3 / 2022
Nr. 03 del 07/02/2022
TML n. 3 / 2022 GLICOPIRRONIO PER I SINTOMI DELL’ULCERA PEPTICA
La Food and Drug Administration (FDA) ha approvato il trattamento aggiuntivo con una nuova formulazione (DartislaEdenbridge negli USA; non disponibile in commercio in Italia) in compresse orodispersibili (Orally Disintegrating Tablet, ODT) del farmaco anticolinergico glicopirronio, per ridurre i sintomi dell’ulcera peptica. Le compresse orali di glicopirronio (Glycolate-Intas Pharmaceuticals, disponibile in Italia per il solo uso ospedaliero) erano state approvate negli Stati Uniti per la stessa indicazione nel 1961.
GLICOPIRRONIO – Il glicopirronio riduce il volume e l’acidità delle secrezioni gastriche; non è chiaro se questi effetti allevino il dolore o promuovano la guarigione dell’ulcera peptica. Mancano studi di ampie dimensioni randomizzati e controllati sulla sua efficacia per il trattamento dei sintomi dell’ulcera peptica da solo o in aggiunta alla terapia antisecretoria con un inibitore della pompa protonica (PPI) o un antagonista del recettore H2 (H2RA).
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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