The Medical Letter TML n. 4/2017
Nr. 04 del 15/02/2017
TML n. 4/2017 – TENOFOVIR ALAFENAMIDE PER L’EPATITE B
La US Food and Drug Administration (FDA) ha approvato il tenofovir alafenamide (Vemlidy-Gilead negli USA; approvato in Europa; non disponibile in commercio in Italia) per il trattamento dell’infezione cronica da virus dell’epatite B (HBV) negli adulti con malattia epatica compensata. Si tratta del primo prodotto a base di un unico farmaco contenente il tenofovir alafenamide (TAF), un profarmaco dell’inibitore nucleotidico della trascrittasi inversa tenofovir, a essere disponibile; esistono diversi prodotti di associazione a base di TAF approvati per il trattamento dell’infezione da HIV-1. Il tenofovir disoproxil fumarato (TDF; Viread-Gilead Sciences), un altro profarmaco del tenofovir, viene utilizzato da diversi anni per il trattamento dell’infezione cronica da HBV.
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