The Medical Letter TML n. 5/2011
Nr. 05 del 01/03/2011
TML n. 5/2011 – IN BREVE: Denosumab per le metastasi ossee
La FDA, che aveva in precedenza approvato il denosumab (Prolia-Amgen; approvato dall’EMA nel maggio 2010 e non attualmente disponibile in commercio in Italia) per via sottocutanea (SC) per il trattamento dell’osteoporosi postmenopausale (1), ha ora approvato un prodotto contenente lo stesso principio attivo a un dosaggio differente (Xgeva-Amgen, in USA; in corso di registrazione nei paesi dell’Unione Europea) per la prevenzione di eventi correlati all’apparato scheletrico (fratture patologiche, compressione midollare o radioterapia ossea) in pazienti con metastasi ossee da tumori solidi. Il denosumab è un anticorpo completamente umano diretto contro il ligando di RANK che inibisce la formazione, l’attivazione e la sopravvivenza degli osteoclasti (2).
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
Se sei già abbonato accedi.
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