The Medical Letter n. 6 / 2021
Nr. 06 del 15/03/2021
TML n.6 / 2021 VERICIGUAT PER L’INSUFFICIENZA CARDIACA
La FDA ha approvato il vericiguat (Verquvo-Merck negli USA; in corso di valutazione da parte dell’EMA), uno stimolatore della guanilato ciclasi solubile (sGC) orale, per ridurre il rischio di ricovero per insufficienza cardiaca e di morte cardiovascolare (CV) a seguito di un peggioramento dell’insufficienza cardiaca (ricovero per insufficienza cardiaca o trattamento con diuretici EV in regime ambulatoriale) in pazienti con insufficienza cardiaca cronica sintomatica e frazione di eiezione ventricolare sinistra (LVEF) < 45%. Il vericiguat è il secondo stimolatore della sGC immesso sul mercato statunitense dopo il riociguat (Adempas-MSD Italia), approvato dalla FDA per il trattamento dell’ipertensione arteriosa polmonare e dell’ipertensione polmonare tromboembolica cronica.
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