The Medical Letter TML n. 6/2012
Nr. 06 del 15/03/2012
TML n. 6/2012 – IN BREVE: Interruzione anticipata di uno studio clinico sull’aliskiren
Uno studio randomizzato, controllato con placebo, che ha valutato l’aggiunta dell’inibitore diretto della renina aliskiren (Rasilez-Novartis Farma) a un inibitore dell’enzima di conversione dell’angiotensina (ACE) o a un bloccante del recettore per l’angiotensina (ARB) in 8606 pazienti con diabete tipo 2 e insufficienza renale (studio ALTITUDE), è stato interrotto anticipatamente dal produttore nel dicembre 2011 perché l’incidenza combinata di eventi cardiovascolari e renali è stata più alta nei pazienti trattati con aliskiren rispetto a quelli del gruppo placebo (1).
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