The Medical Letter TML n. 6/2015
Nr. 06 del 15/03/2015
TML n. 6/2015 – METRELEPTINA – Un analogo della leptina per la lipodistrofia generalizzata
La metreleptina (Myalept, in USA; non disponibile in commercio in Italia), un analogo ricombinante della leptina prodotto nell’E. coli, è stato approvato dalla US Food and Drug Administration (FDA) per il trattamento delle complicanze da carenza di leptina nei pazienti affetti da lipodistrofia generalizzata congenita o acquisita. Ad oggi non è stata approvata per il trattamento delle lipodistrofie parziali, comprese quelle che accompagnano l’impiego di inibitori delle proteasi nei pazienti con HIV. In Giappone la metreleptina è approvata per il trattamento di qualsiasi disturbo lipodistrofico.
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