The Medical Letter TML n. 6/2016
Nr. 06 del 15/03/2016
TML n. 6/2016 – ELVITEGRAVIR PER L’HIV
La US Food and Drug Administration (FDA) ha approvato l’elvitegravir (Vitekta-Gilead negli USA approvato in Europa, ma non disponibile in commercio in Italia), un inibitore dell’attività di strand transfer dell’integrasi (INSTI), per l’uso con un inibitore delle proteasi (PI) più ritonavir e altri farmaci antiretrovirali per il trattamento dell’infezione da HIV-1 in adulti già sottoposti a terapia. L’elvitegravir è disponibile anche come associazione precostituita (Stribild-Gilead) insieme al potenziatore farmacocinetico cobicistat e agli inibitori nucleosidici/nucleotidici della trascrittasi inversa (NRTI) emtricitabina e tenofovir disoproxil fumarato (DF) (1). Un’associazione simile (Genvoya-Gilead negli USA; approvato in Europa, ma non disponibile in commercio in Italia), contenente il tenofovir alafenamide al posto del tenofovir DF, è stata di recente approvata dalla FDA e verrà trattata in un prossimo numero.
Questo è l'abstract dell'articolo. Per poter consultare l'intero numero o più numeri scegli il tipo di abbonamento che preferisci.
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