The Medical Letter n. 7 / 2021
Nr. 07 del 01/04/2021
TML n.7 / 2021 IPERTENSIONE CON ERENUMAB
Nel 2018 la Food and Drug Administration (FDA) ha approvato l’antagonista del recettore del gene della calcitonina (CGRP), somministato per via sottocutanea una volta al mese, erenumab-aooe (Aimovig-Novartis) per il trattamento preventivo dell’emicrania negli adulti. Ora la FDA ha aggiunto un nuovo avvertimento alla scheda informativa relativo al rischio di ipertensione di nuova insorgenza e di peggioramento dell’ipertensione preesistente associato all’uso del farmaco. Il CGRP è un potente vasodilatatore microvascolare; il blocco o l’eliminazione hanno prodotto effetti ipertensivi negli animali.
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