The Medical Letter TML n. 7/2011
Nr. 07 del 01/04/2011
TML n. 7/2011 – TRATTAMENTO DELL’INFEZIONE DA CLOSTRIDIUM DIFFICILE
L’infezione da Clostridium difficile (ICD) è la più frequente causa di diarrea di origine infettiva associata a ricovero in strutture sanitarie negli adulti. Negli ultimi anni si è assistito a un aumento dell’incidenza e della gravità dell’ICD in seguito alla comparsa di un ceppo epidemico ad elevata virulenza (NAP1/BI/027) (1, 2). Comuni fattori di rischio sono il ricovero in una struttura sanitaria, l’età avanzata e la gravità della malattia di base, la soppressione acida gastrica e l’esposizione a terapie antimicrobiche, in particolare a clindamicina, ampicillina, cefalosporine o fluorochinoloni (3, 4). Nei pazienti che sviluppano una ICD durante il trattamento con un antibiotico, è necessario sospendere, se possibile, la terapia antibiotica, o passare a un altro antimicrobico con un minor rischio di ICD (5).
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