The Medical Letter TML n. 7/2012
Nr. 07 del 01/04/2012
TML n. 7/2012 – CRIZOTINIB PER IL CARCINOMA POLMONARE NON A PICCOLE CELLULE
La US Food and Drug Administration (FDA) ha approvato il crizotinib (Xalkori-Pfizer, negli USA; in attesa di approvazione in Europa), un inibitore delle tirosin-chinasi per via orale, per il trattamento del carcinoma polmonare non a piccole cellule (NSCLC, non-small cell lung cancer) in fase localmente avanzata o metastatica in pazienti con traslocazione ALK (chinasi del linfoma anaplastico), che è presente nel 4-5% circa dei carcinomi del polmone non a piccole cellule. È disponibile un test diagnostico (Vysis ALK Break Apart FISH Probe Kit-Abbott Molecular) per rilevare le traslocazioni del gene ALK nei campioni di tessuto tumorale; queste traslocazioni si verificano principalmente in soggetti non fumatori affetti da adenocarcinoma polmonare.
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