The Medical Letter TML n. 7/2017
Nr. 07 del 01/04/2017
TML n. 7/2017 – PEMBROLIZUMAB PER IL TRATTAMENTO DI PRIMA LINEA DELL’NSCLC METASTATICO
La US Food and Drug Administration (FDA) ha approvato l’inibitore del checkpoint immunitario pembrolizumab (Keytruda-MSD Italia), un inibitore del recettore PD-1 (proteina di morte programmata), per il trattamento di prima linea dei pazienti affetti da carcinoma polmonare non a piccole cellule (NSCLC) metastatico con elevata espressione del PD-L1 (ligando 1 della proteina di morte programmata) e senza mutazioni EGFR (recettore del fattore di crescita epidermico) o traslocazioni ALK (chinasi del linfoma anaplastico). Circa il 25% dei pazienti con NSCLC avanzato presenta tumori con livelli elevati di espressione del PD-L1 (PD-L1 espresso su una percentuale di cellule tumorali ≥ 50%). Il pembrolizumab è stato approvato in precedenza per il trattamento dell’NSCLC metastatico con espressione del PD-L1 ≥ 1% che ha progredito durante o dopo la chemioterapia a base di platino (1).
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