The Medical Letter TML n. 7/2019
Nr. 07 del 01/04/2019
TML n. 7/2019 OXIBUTININA PER LE VAMPATE DI CALORE NELLE DONNE CON CARCINOMA MAMMARIO
I risultati ad interim di uno studio in doppio cieco, controllato con placebo hanno indicato che l’uso off-label del farmaco anticolinergico oxibutinina può ridurre la frequenza e la gravità delle vampate di calore nelle donne con carcinoma mammario. È stato dimostrato che l’oxibutinina orale a rilascio prolungato (Lyrinel-Janssen-Cilag) riduce la frequenza e la gravità delle vampate di calore nelle donne sane in menopausa.
VAMPATE DI CALORE – I sintomi vasomotori (vampate di calore) si verificano nella maggior parte delle donne in menopausa e possono avere un’influenza significativa sulla qualità della vita. Nelle donne con un’anamnesi di carcinoma mammario, sono comuni vampate di calore severe a causa della carenza di estrogeni a esordio precoce indotta dalla chemioterapia o dalla ovariectomia e dell’utilizzo di farmaci antiestrogeni come il tamoxifene e gli inibitori dell’aromatasi.
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