The Medical Letter TML n. 9 / 2024
Nr. 09 del 29/04/2024
TML n. 9 / 2024 Resmetirom per la steatoepatite associata a disfunzione metabolica
Il resmetirom (Rezdiffra Madrigal, in USA; non disponibile in commercio in Italia), un agonista del recettore beta dell'ormone tiroideo, ha ricevuto un'approvazione accelerata da parte della US Food and Drug Administration (FDA) per il trattamento della steatoepatite non alcolica (nonalcoholic steatohepatitis, NASH) non cirrotica con fibrosi moderata o avanzata negli adulti. La NASH è stata recentemente rinominata steatoepatite associata a disfunzione metabolica (metabolic disfunction-associated steatohepatitis, MASH). Il resmetirom è il primo farmaco ad essere approvato negli Stati Uniti per questa indicazione.
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