The Medical Letter TML n. 9/2014
Nr. 09 del 01/05/2014
TML n. 9/2014 – RIOCIGUAT PER L’IPERTENSIONE ARTERIOSA POLMONARE
La US Food and Drug Administration ha approvato il riociguat (Adempas-Bayer, negli USA), uno stimolatore della guanilato ciclasi solubile (sGC, soluble guanylate cyclase), per il trattamento per via orale dell’ipertensione arteriosa polmonare (IAP; acronimo anglosassone: PAH, pulmonary arterial hypertension) e per il trattamento dell’ipertensione polmonare tromboembolica cronica (CTEPH, chronic thromboembolic pulmonary hypertension) in pazienti che sono stati sottoposti a un intervento chirurgico o in quelli non candidabili a un intervento chirurgico. È il primo farmaco approvato per il trattamento della CTEPH. Nell’Unione Europea il riociguat ha ricevuto la designazione di farmaco orfano ed è stato approvato dall’EMA il 31 marzo 2014 con il nome di Adempas per l’impiego nella CTEPH e nella PAH.
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