The Medical Letter TML n. 9/2017
Nr. 09 del 01/05/2017
TML n. 9/2017 – Interazioni farmacologiche: Clopidogrel e PPI
Il farmaco antiaggregante clopidogrel (Plavix-Sanofi e altri; disponibile anche come medicinale equivalente) riduce gli eventi cardiovascolari maggiori, ma può provocare sanguinamento. Gli inibitori della pompa protonica (PPI) vengono spesso usati con il clopidogrel per prevenire l’emorragia gastrointestinale; tuttavia, alcune evidenze suggeriscono che i PPI possano interferire con l’attivazione del clopidogrel e diminuirne l’effetto antiaggregante (1). La scheda tecnica approvata dalla FDA raccomanda di evitare l’uso concomitante dei PPI omeprazolo ed esomeprazolo con il clopidogrel.
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